Description: Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, and decreases tau hyperphosphorylation. Target:...

Manzamine A is a beta-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica. It is an inhibitor of glycogen synthase kinase 3beta (GSK3beta) and cyclin-dependent kinase 5 (CDK5, IC50s = 10.2 and 1.5 µM, respectively). It inhibits the growth of L5178y mouse lymphoma...

Manzamine A is an alkaloid isolated from marine sponges. Manzamine A exhibits neuroprotective, anticancer, anti-hyperlipidemic, anti-atherosclerotic, antibiotic, and antiviral activities. In vitro, manzamine A uncouples vacuolar ATPases, inhibiting autophagy and tumor growth. Manzamine A inhibits foam cell...

Manzamine A is an alkaloid isolated from marine sponges. Manzamine A exhibits neuroprotective, anticancer, anti-hyperlipidemic, anti-atherosclerotic, antibiotic, and antiviral activities. In vitro, manzamine A uncouples vacuolar ATPases, inhibiting autophagy and tumor growth. Manzamine A inhibits foam cell formation...