- Search results for 1033739-92-2
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2 products were found matching "1033739-92-2"!
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Item number: Cay41120-1
GNE-490 is an inhibitor of PI3K (IC50s = 3.5, 25, 5.2, and 15 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, and PI3Kgamma, respectively). It is selective for PI3K over mTOR (IC50 = 740 nM) and a panel of 142 kinases at 1 µM. GNE-490 (0.4 µM) reduces cell migration by, the number of vessel outgrowths from, and induces...
Keywords: | 2-(2-amino-4-methyl-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine-6-methanol |
Application: | PI3K inhibitor |
CAS | 1033739-92-2 |
MW: | 386.5 D |
From 114.00€
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Item number: SYN-1114-M001
Soluble in DMSO. GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR. It has good pharmacokinetic (PK) parameters and demonstrates knock down of pathway markers in vivo. Originally obtained via modification of compounds like GDC-0941, GNE-490 which have a significantly reduced...
Keywords: | GNE490 |
Application: | PI3K inhibitor |
CAS | 1033739-92-2 |
MW: | 386,5 D |
From 250.00€
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