Description: DMU2105 is a specific CYP1B1 inhibitor(CYP1B1 and CYP1A1 with IC50 of 10 nM and 742 nM, respectively). Target: P450. Smiles: C(=CC(=O)C=1C=CC=NC1)C2=CC3=C(C=C2)C=CC=C3. References: Horley N J , Beresford K J M , Chawla T , et al. Discovery and characterization of novel CYP1B1 inhibitors based on...

DMU2105 is an inhibitor of the cytochrome P450 (CYP) isoform CYP1B1 (IC50 = 0.01 µM). It is selective for CYP1B1 over CYP1A1, CYP1A2, CYP3A4, and CYP2D6 (IC50s = 0.742, 1.2, 18, and 10 µM, respectively). DMU2105 enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1.Formal Name:...