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Item number: TGM-T2650-10mg

Description: MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function. Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD). Smiles: OC(=O)Cn1nnc(n1)-c1cc(no1)N1CCC(CC1)Oc1cc(F)ccc1Br. References: Oballa RM, et al....

CAS	1030612-90-8
MW:	467.25 D

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MK-8245

Item number: Cay29421-10

MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD, IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Delta5- and Delta6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to...

Keywords:	5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
Application:	Stearoyl-CoA desaturase inhibitor
CAS	1030612-90-8
MW:	467.3 D

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