Description: 8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells. Target: Adenosine deaminase. Smiles: Nc1ncnc2n(nnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O. References: Bennett L L...

8-Azaadenosine is a purine nucleoside analog and an inhibitor of adenosine deaminase acting on RNA 1 (ADAR1), an enzyme that converts adenosine to inosine in dsRNA, a post-transcriptional modification known as A-to-I editing. It inhibits RNA A-to-I editing in, as well as the invasion and migration of, TPC-1 and...