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SGI-1776
Item number: TGM-T3078-100mg
Description: SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias. Target: Pim, Autophagy, FLT, Apoptosis. Smiles: CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1. References: Chen LS, et al. Blood, 2011,...
| Keywords: | Pim-Kinase Inhibitor IX, SGI-1776 free base |
| Application: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405.42 D |
From 48.00€
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SGI-1776
Item number: Cay16423-1
The Pim family proteins are serine/threonine kinases involved in cancer progression. SGI-1776 is a potent inhibitor of all three human Pim kinases (IC50s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively). While it also inhibits FLT3 and haspin (IC50s = 44 and 34 nM, respectively), SGI-1776 has little...
| Keywords: | Pim-Kinase Inhibitor IX, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine |
| Application: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405.4 D |
From 44.00€
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SGI-1776
Item number: SYN-1193-M001
Soluble in DMSO or ethanol. SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. Target: Pim1 - Pim2 - Pim3 , Kinase Group: CAMK , Substrate: Serine-Threonine
| Keywords: | SGI1776 |
| Application: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405,4 D |
From 123.00€
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