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SGI-1027
Item number: TGM-T1904-100mg
Description: SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 µM, respectively. Target: DNA Methyltransferase, Apoptosis. Smiles:...
| Keywords: | SGI1027, DNA Methyltransferase Inhibitor II |
| Application: | DNMT1 / DNMT3A / DNMT3B inhibitor |
| CAS | 1020149-73-8 |
| MW: | 461.52 D |
From 54.00€
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SGI-1027
Item number: Cay11165-10
SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 µM, respectively, with Poly(dI-dC) as the substrate). It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation.Formal Name:...
| Keywords: | DNA Methyltransferase Inhibitor II, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-benzamide |
| Application: | DNMT1 / DNMT3A / DNMT3B inhibitor |
| CAS | 1020149-73-8 |
| MW: | 461.5 D |
From 52.00€
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