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ML-030
Item number: TGM-T5496-100mg
Description: ML-030 is a potent and selective inhibitor of PDE4(PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2 with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM, respectively). Target: PDE. Smiles: COc1ccc(OC)c(c1)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1. References: Skoumbourdis AP, et al. Exploration...
| Application: | PDE4 inhibitor |
| CAS | 1013750-77-0 |
| MW: | 412.46 D |
From 37.00€
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ML-030
Item number: Cay15169-1
Type 4 cyclic nucleotide phosphodiesterases (PDE4s), which are highly expressed in neutrophils and monocytes, selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Inhibition of PDE4 activity has been examined in the context of treating asthma, chronic obstructive...
| Keywords: | CID-11757146, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine |
| Application: | PDE4 inhibitor |
| CAS | 1013750-77-0 |
| MW: | 412.5 D |
From 61.00€
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