30 products were found matching "916,"!

Description: NITD-916 is an orally active and highly lipophilic inhibitor of Mycobacterium enoyl reductase InhA with an IC50 of 570 nM.NITD-916 is a potent 4-hydroxy-2-pyridone derivative that forms a ternary complex with InhA and NADH, preventing access to the fatty acyl substrate-binding pocket.NITD-916 exhibits...

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. MUC6 or gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach...

1 mg/ml in sterile PBS, BSA free, sodium azide free. MUC6 or gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall...

Cyazofamid is a fungicide. It is active against several isolates of P. infestans, as well as P. sojae, P. aphanidermatum, P. paddicum, P. sylvaticum, and A. cochlioides (EC50s = 0.008-0.03, 0.2, 0.02, 0.2, 0.2, and 0.2 µg/ml, respectively). Cyazofamid (10 µM) selectively inhibits P. spinosum mitochondrial complex...

PathPlex Panel 4 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the context of the tumor microenvironment. Antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin) express immune checkpoint ligands such as PD-L1 which inhibits the ability of...

PathPlex Panel 5 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and cells expressing the immune checkpoint ligand PD-L1 within the context of the tumor microenvironment. PD-L1 can be expressed on antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin). Ki-67 is a proliferation...

PathPlex Panel 8 identifies total T-cells (CD3), T-helper cells (CD4), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the tumor microenvironment. Lag3 is a checkpoint inhibitor which identifies exhausted T-cells. Tumor cells are identified by cytokeratin.

PathPlex Panel 6 identifies total T-cells (CD3) and cytotoxic T-cells (CD8) and activated cytotoxic T-cells (Granzyme B) within the tumor microenvironment. The inclusion of multiple tumor cell makers (cytokeratin, Sox10 and Ki-67) provides flexibility across multiple tumor types.

Description: VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor. Target: HCV Protease. Smiles: N(C(=O)[C@@H]1CC[C@@H](C)CC1)(C2=C(C(O)=O)SC(=C2)C=3CCCCC3)[C@@H]4CC[C@@H](OC)CC4. References: Ludmila Gerber, Tania M. Welzel, Stefan Zeuzem. New therapeutic strategies in HCV: polymerase inhibitors. Liver...

Description: APD-916 dicitrate is a potent and selective inverse agonist of the histamine H3 receptor. Target: Others

Description: L 583916 is a bioactive chemical. L 583916 does not inhibit leukotriene synthesis. Target: Others. Smiles: O=C(O)C(C=1C=2C=C(OC)C=CC2N(C(=O)C3=CC=C(Cl)C=C3)C1C)C. References: Kargman S, Vickers PJ, Evans JF. A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells. J Cell Biol. 1992...

Description: VCH-916 is a new nonnucleoside inhibitor of HCV NS5B polymerase. Target: HCV Protease. Smiles: O=C(C1=C(N([C@H]2CC[C@H](OC)CC2)C([C@H]3CC[C@H](C)CC3)=O)C=C(C4=CCCCC4)S1)O[K]. References: Abdelrahman S. Mayhoub. Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure-activity and...