Voltage-dependent L-type calcium channel subunit alpha-1C (Cacna1c), partial, mouse, recombinant

Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1689-2139aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-GFP-tagged. Target Protein Sequence: AASEDDIFRR AGGLFGNHVT YYQSDSRGNF PQTFATQRPL HINKTGNNQA DTESPSHEKL VDSTFTPSSY SSTGSNANIN NANNTALGRF PHPAGYSSTV STVEGHGPPL SPAVRVQEAA WKLSSKRCHS RESQGATVNQ EIFPDETRSV RMSEEAEYCS EPSLLSTDMF SYQEDEHRQL TCPEEDKREI QPSPKRSFLR SASLGRRASF HLECLKRQKD QGGDISQKTA LPLHLVHHQA LAVAGLSPLL QRSHSPTTFP RPCPTPPVTP GSRGRPLRPI PTLRLEGAES SEKLNSSFPS IHCSSWSEET TACSGSSSMA RRARPVSLTV PSQAGAPGRQ FHGSASSLVE AVLISEGLGQ FAQDPKFIEV TTQELADACD MTIEEMENAA DNILSGGAQQ SPNGTLLPFV NCRDPGQDRA VAPEDESCAY ALGRGRSEEA LADSRSYVSN L. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: n/a. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). Reference: n/a. Function: nan