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![Transcriptional enhancer factor TEF-4 (TEAD2), partial, human, recombinant](https://www.biomol.com/media/image/40/a5/ac/CSB-EP613597HU2-1_600x600.jpg)
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Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 217-447aa. Protein Length:... more
Product information "Transcriptional enhancer factor TEF-4 (TEAD2), partial, human, recombinant"
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 217-447aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: AWQARGLGTA RLQLVEFSAF VEPPDAVDSY QRHLFVHISQ HCPSPGAPPL ESVDVRQIYD KFPEKKGGLR ELYDRGPPHA FFLVKFWADL NWGPSGEEAG AGGSISSGGF YGVSSQYESL EHMTLTCSSK VCSFGKQVVE KVETERAQLE DGRFVYRLLR SPMCEYLVNF LHKLRQLPER YMMNSVLENF TILQVVTNRD TQELLLCTAY VFEVSTSERG AQHHIYRLVR D. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Reference: "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition." Zhang H., Liu C.Y., Zha Z.Y., Zhao B., Yao J., Zhao S., Xiong Y., Lei Q.Y., Guan K.L. J. Biol. Chem. 284:13355-13362(2009). Function: nan
Keywords: | TEF4, TEAD2, TEAD-2, TEA domain family member 2, Transcriptional enhancer factor TEF-4, Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial |
Supplier: | Cusabio |
Supplier-Nr: | EP613597HU2 |
Properties
Application: | Activity not tested |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 33.7 kD |
Purity: | >85% (SDS-PAGE) |
Database Information
KEGG ID : | K09448 | Matching products |
UniProt ID : | Q15562 | Matching products |
Gene ID | GeneID 8463 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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