TNFRSF9 Protein (Fc Tag) (recombinant human)

Sequence: Leu24-Gln186. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 50-60 kDa. Protein function: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. Protein function: Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable). [The UniProt Consortium]