TNF Receptor II/TNF RII/TNFRSF1B/CD120b (C-6His-Avi) Biotinylated (recombinant mouse)

Protein Construction: Biotinylated Recombinant Mouse Tumor Necrosis Factor Receptor II is produced by our Mammalian expression system and the target gene encoding Val23-Gly258 is expressed with a 6His, Avi tag at the C-terminus. Sequence: Val23-Gly258. Fusion tag: C-6His-Avi Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 35-50 kDa. Protein function: Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) is a member of the Tumor Necrosis Factor Receptor Superfamily. TNFRSF1B contains four TNFR-Cys repeats. TNFRSF1B can be cleaved into the following 2 chains: Tumor necrosis factor receptor superfamily member 1b and membrane form and Tumor necrosis factor-binding protein 2. TNFRSF1B is a receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. TNFRSF1B mediates most of the metabolic effects of TNF-alpha. TNF-alpha-induced apoptosis suggests that it regulates TNF-alpha function by antagonizing its biological activity.