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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay11522-100 | 100 µg | - | - |
6 - 10 business days* |
409.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Truncated thioredoxin 1 (Trx80) is a C-terminally truncated cleavage product of the... more
Product information "Thioredoxin 80 (human, recombinant)"
Truncated thioredoxin 1 (Trx80) is a C-terminally truncated cleavage product of the oxidoreductase Trx1 that acts as a cytokine. It is expressed primarily in monocytes but also in T cells, activated platelets, and cytotrophoblasts, and localizes to the cell surface. Trx80 contains three cysteines but does not have oxidoreductase activity, and, unlike Trx, it forms homodimers. It induces proliferation of, and increases the expression of CD14, CD40, CD54, and CD86 in, monocytes, as well as enhances eosinophil-induced cytotoxicity of schistosomes and the secretion of IL-12 and IFN-gamma in peripheral blood mononuclear cells (PBMCs). It also acts as a chemoattractant for monocytes, T cells, and neutrophils. Trx80-activated monocytes inhibit growth of the bacteria L. monocytogenes and B. abortus by inducing their accumulation in lysosomes, but Trx80 increases replication of HIV in infected macrophages. It inhibits amyloid-beta (Abeta) aggregation in cell-free assays and reduces the toxicity of Abeta in SH-SY5Y cells. Levels of Trx80 are reduced in postmortem brain tissue from patients with Alzheimer's disease.Synonyms: ECEF, Eosinophil Cytotoxicity-enhancing Factor, Truncated Thioredoxin 1, Trx80, Txn80. Purity: >85% estimated by SDS-PAGE. Source: Recombinant human thioredoxin 80 expressed in E. coli. Amino Acids: 1-80. MW: 9.04 kDa. Formulation: (Request formulation change), Lyophilized in PBS, pH 7.4. UniProt Accession #: P10599.
Keywords: | Trx1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11522 |
Properties
Application: | Control |
Conjugate: | No |
Purity: | >85% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K03671 | Matching products |
UniProt ID : | P10599 | Matching products |
Gene ID : | GeneID 7295 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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