TEAD3 Cofactor-Binding Domain (human, recombinant)

TEA domain transcription factor 3 (TEAD3) is a transcription factor and member of the TEA domain-containing family of transcription factors. It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds tafazzin (TAZ) or YES-associated transcriptional regulator (YAP), or vestigial-like proteins (VGLLs), and is involved in TAZ-, YAP-, or VGLL-dependent transcription of genes in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death. TEAD3 associates with VGLL3 to regulate growth and differentiation in primary mouse myoblasts and primary mouse myotubes. The tertiary structure and function of TEAD3 require C-terminal palmitoylation at residue 371. Increased tumor levels of TEAD3 are associated with decreased survival time, increased liver metastases, and reduced time of disease-free survival in patients with pancreatic ductal adenocarcinoma (PDAC). Cayman's TEAD3 Cofactor-Binding Domain (human, recombinant) protein consists of 219 amino acids, has a calculated molecular weight of 28.5 kDa, and is depalmitoylated at cysteine 371.Synonyms: DTEF-1, ETFR-1, Embryonic TEA Domain-containing Factor 1, TEF-5, TEA Domain-containing Factor 1, TEA Domain Family Member 3, TEA Domain Transcription Factor 3, Transcriptional Enhancer Factor 5. Source: Recombinant human N-terminal His-tagged TEAD3 cofactor-binding domain expressed in insect cells. Amino Acids: 216-435. MW: 28.5 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 7.5, 200 mM sodium chloride, 20% glycerol, and 1 mM DTT. UniProt Accession No: Q99594.