TEAD2 Cofactor-Binding Domain (human, recombinant)

TEA domain transcription factor 2 (TEAD2) is a transcription factor and member of the TEA domain-containing family of transcription factors. It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds tafazzin (TAZ), YES-associated transcriptional regulator (YAP), or vestigial-like proteins (VGLLs), and is involved in TAZ-, YAP-, or VGLL-dependent transcription of genes in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death. The tertiary structure and function of TEAD2 requires C-terminal palmitoylation at residue 380. TEAD2 binds to the promoter for Pou5f1, the gene encoding octamer-binding transcription factor 3 (Oct3), and is necessary for mouse embryonic stem cell self-renewal. Increased tumor levels of TEAD2 mRNA are associated with poor survival, angiogenesis, tumor progression, and increased expression of genes associated with the epithelial-to-mesenchymal transition (EMT) in patients with hepatocellular carcinoma (HCC). Cayman's TEAD2 Cofactor-Binding Domain (human, recombinant) protein consists of 230 amino acids, has a calculated molecular weight of 26.4 kDa, and is depalmitoylated at cysteine 380.Synonyms: Embryonic TEA Domain-containing Factor, ETF, TEA Domain Family Member 2, TEA Domain Transcription Factor 2, TEF-4, Transcriptional Enhancer Factor 4. Source: Recombinant human TEAD2 cofactor-binding domain expressed in insect cells. Amino Acids: 217-447. MW: 26.4 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 7.5, with 200 mM sodium chloride, 20% glycerol, and 1 mM DTT. UniProt Accession No: Q15562.