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![T-lymphocyte activation antigen CD86 (CD86), partial (Active), human, recombinant](https://www.biomol.com/media/image/23/68/d8/CSB-AP005161HU-1_600x600.jpg)
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 24-247aa. Protein... more
Product information "T-lymphocyte activation antigen CD86 (CD86), partial (Active), human, recombinant"
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 24-247aa. Protein Length: Extracellular Domain. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: APLKIQAYFN ETADLPCQFA NSQNQSLSEL VVFWQDQENL VLNEVYLGKE KFDSVHSKYM GRTSFDSDSW TLRLHNLQIK DKGLYQCIIH HKKPTGMIRI HQMNSELSVL ANFSQPEIVP ISNITENVYI NLTCSSIHGY PEPKKMSVLL RTKNSTIEYD GIMQKSQDNV TELYDVSISL SVSFPDVTSN MTIFCILETD KTRLLSSPFS IELEDPQPPP DHIP. Purity: Greater than 95% as determined by SDS-PAGE. Endotoxin: Less than 1.0 EU/µg as determined by LAL method. Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CTLA-4-Fc-Avi at 5µg/ml can bind Human B7-2-His, the ED50 of Recombinant Human B7-2-His is 1.19 µg/ml. Form: Lyophilized powder. Buffer: Lyophilized from a 0.2 µm filtered 20 mM PB, 150 mM NaCl, pH 7.2. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain. Reference: n/a. Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation., FUNCTION
Keywords: | B70, BU63, CD86, FUN-1, CD28LG2, Activation B7-2 antigen, CTLA-4 counter-receptor B7.2, T-lymphocyte activation antigen CD86, Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) |
Supplier: | Cusabio |
Supplier-Nr: | AP005161HU |
Properties
Application: | Active protein |
Conjugate: | No |
Host: | Mammalian cells |
Species reactivity: | human |
MW: | 26.69 kD |
Purity: | >95% (SDS-PAGE) |
Format: | Lyophilized |
Database Information
KEGG ID : | K05413 | Matching products |
UniProt ID : | P42081 | Matching products |
Gene ID | GeneID 942 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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