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![SUMO2 (human) (rec.) (Rhodamine 110)](https://www.biomol.com/media/image/d3/43/44/SBB-PS0029-C050_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
SBB-PS0029-C050 | 50 µg | - | - |
3 - 9 business days* |
497.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
SUMO2 is a Ubiquitin-like protein (UBL) that can be covalently attached to proteins as a monomer... more
Product information "SUMO2 (human) (rec.) (Rhodamine 110)"
SUMO2 is a Ubiquitin-like protein (UBL) that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. This SUMO2 substrate is C-terminally derivatized with a bis-Gly-Rhodamine 110 fluorophore. The bis-Gly-Rh110 is quenched until the amide bond between the C-terminal glycine and the rhodamine compound is hydrolyzed. The efficiency of quenching combined with the powerful signal upon hydrolysis yields an unparalleled signal-to-background. SUMO2-Rh110 can be used to study the deSUMOylating activity of hydrolases SENP1 and SENP2, among other deSUMOylating enzymes. The substrate activity of SUMO2-Rhodamine 110 was determined by measuring the SENP1 catalyzed release of unquenched Gly-Rh-110.
Keywords: | Small Ubiquitin-related Modifier 2, HSMT3, SMT3 Homolog 2, Sentrin-2, Ubiquitin-like Protein SMT3A |
Supplier: | South Bay Bio |
Supplier-Nr: | PS0029 |
Properties
Application: | Assays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 11 kD |
Purity: | >97% |
Format: | Liquid |
Database Information
KEGG ID : | K12160 | Matching products |
UniProt ID : | P61956 | Matching products |
Gene ID | GeneID 6613 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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