SUMO1 (UBL1) protein-HIS Epitope

SUMO1 (UBL1) protein-HIS Epitope
Item number Size Datasheet Manual SDS Delivery time Quantity Price
009-001-T66 50 µg - -

6 - 10 business days*

402.00€
 
Recombinant human SUMO1 (UBL1) (2-97) was expressed in E. coli using an N-Terminal his epitope.... more
Product information "SUMO1 (UBL1) protein-HIS Epitope"
Recombinant human SUMO1 (UBL1) (2-97) was expressed in E. coli using an N-Terminal his epitope. The purity was determined to be >90% by densitometry. Protein function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1, this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). [The UniProt Consortium]
Keywords: GMP1, SMT3C, Smt3C, SUMO1, SUMO-1, Sentrin, SMT3 homolog 3, GAP-modifying protein 1, Ubiquitin-like protein UBL1, Ubiquitin-like protein SMT3C, Small ubiquitin-related modifier 1, Ubiquitin-homology domain protein PIC1
Supplier: Rockland Immunochemicals
Supplier-Nr: 009-001-T66

Properties

Application: WB
Conjugate: No
Host: Human

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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