STING Y240A variant (Y240A mutant, human, recombinant)

Stimulator of interferon genes (STING) is a component of the innate immune response that recognizes and binds to cyclic dinucleotides (CDNs), which either originate from bacteria or are signals of intracellular stress, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project. STING is composed of four transmembrane domains at the N-terminus, a helix alpha1 domain involved in protein dimerization and ligand sensing, and a cytoplasmic C-terminal domain containing the cyclic dinucleotide-binding domain, as well as the TBK1/IRF1-binding site, TBK1 phosphorylation site, and IRF3 docking site. Various mutations in STING either reduce or increase its activity or binding affinity. The tyrosine-to-alanine substitution at position 240 (Y240A) reduces 2'3'-cGAMP binding to STING and prevents activation of the IFN pathway.Synonyms: Endoplasmic Reticulum Interferon Stimulator, ERIS, Mediator of IRF3 Activation, MITA, Mitochondrial Mediator of IRF3 Activation, MPYS, Stimulator of Interferon Genes, Stimulator of Interferon Response cGAMP Interactor 1, STING1, N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner, Transmembrane Protein 173, TMEM173. Purity: >75% estimated by SDS-PAGE. Source: Recombinant human N-terminal His-tagged STING R232 variant (Y240A mutant) expressed in E. coli. Amino Acids: 138-379. MW: 28.73 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, 100 mM sodium chloride, 10% glycerol. UniProt Accession No: Q86WV6.