SSTR2 (human) full length protein-MNP

Item number Size Datasheet Manual SDS Delivery time Quantity Price
DIM-FLP100012.50 50 µg - -

7 - 16 business days*

1,680.00€
DIM-FLP100012.100 100 µg - -

7 - 16 business days*

2,240.00€
 
Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including... more
Product information "SSTR2 (human) full length protein-MNP"
Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity, and low side effects. DIMA biotech developed an optimized MNPs platform for the full-length membrane protein productions using membrane coating technology and HEK293 based expression platform. The high-purity plasma membrane-coated nanoparticles were produced by extrusion after membrane extraction from the host HEK293 cells containing the overexpressed target proteins. Protein function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. [The UniProt Consortium]
Keywords: SS2R, SSTR2, SS2-R, SS-2-R, SRIF-1, Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SST2, Human SSTR2 full length protein-MNP
Supplier: DIMA
Supplier-Nr: FLP100012

Properties

Application: Full length transmembrane protein, high biocompatib., ELISA, screening, immunization, cell-based assays
Conjugate: No
Host: Human cells
Species reactivity: human
MW: 41.2 kD
Format: Lyophilized

Handling & Safety

Storage: -20°C (avoid repeat freezing and thawing cycles)
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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