SIRT7 (human, recombinant)

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.Synonyms: NAD-dependent deacetylase 7, Silent Information Regulator 7, Sirtuin 7, SIR2L7, SIR2-like protein 7. Purity: >35% estimated by SDS-PAGE. Source: Recombinant human N-terminal hexahistidine-tagged enzyme expressed in E. coli. Amino Acids: 2-400 (full length). MW: 49.3 kDa. Formulation: (Request formulation change), 50 mM NaPO4, pH 7.2, with 100 mM NaCl and 20% glycerol. UniProt Accession #: Q9NRC8.