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![Signal-Regulatory Protein a-1/SIRPA/CD172a Protein(C-6His) (recombinant mouse)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSM041144.10 | 10 µg | - |
7 - 16 business days* |
103.00€
|
|||
E-PKSM041144.50 | 50 µg | - |
7 - 16 business days* |
297.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Mouse Signal-Regulatory Protein alpha 1 is produced by our... more
Product information "Signal-Regulatory Protein a-1/SIRPA/CD172a Protein(C-6His) (recombinant mouse)"
Protein Construction: Recombinant Mouse Signal-Regulatory Protein alpha 1 is produced by our Mammalian expression system and the target gene encoding Lys32-Asn372 is expressed with a 6His tag at the C-terminus. Sequence: Lys32-Asn372. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 60-110 kDa. Protein function: Mouse Signal Regulatory Protein a (SIRPa) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPa can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPa acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPa shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPa engagement generally produces a negative regulatory signal, it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation
Keywords: | Signal-regulatory protein alpha, Signal-regulatory protein alpha, isoform CRA_a, Tyrosine-protein phosphatase non-receptor type substrate 1, Recombinant Mouse Signal-Regulatory Protein a-1/SIRPA/CD172a Protein(C-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSM041144 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | mouse |
MW: | 38.7 kD |
Format: | Lyophilized |
Database Information
UniProt ID : | Q6P6I8 | Matching products |
Gene ID | GeneID 19261 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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