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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PDMH100228.20 | 20 µg | - | - |
7 - 16 business days* |
248.00€
|
||
E-PDMH100228.100 | 100 µg | - | - |
7 - 16 business days* |
742.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Sequence: Ser42-Ser1045. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as... more
Product information "sCD163 Protein (His Tag) (recombinant human)"
Sequence: Ser42-Ser1045. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 130-140 kDa. Protein function: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Protein function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. [The UniProt Consortium]
Keywords: | M130, CD163, Recombinant Human sCD163 Protein(His Tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PDMH100228 |
Properties
Conjugate: | No |
Host: | Mammalian |
Species reactivity: | human |
Format: | Lyophilized |
Database Information
KEGG ID : | K06545 | Matching products |
UniProt ID : | Q86VB7 | Matching products |
Gene ID | GeneID 9332 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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