SARS-CoV-2 nsp10 (recombinant)

SARS-CoV-2 nsp10 (recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay40883-100 100 µg - -

6 - 10 business days*

731.00€
Cay40883-500 500 µg - -

6 - 10 business days*

2,369.00€
 
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded... more
Product information "SARS-CoV-2 nsp10 (recombinant)"
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus and the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications. The SARS-CoV-2 genome contains approximately 30 kilobases and 14 open reading frames (ORFs) that encode four structural proteins: spike, envelope, membrane, and nucleocapsid, as well as 16 non-structural proteins and 9 accessory factors. SARS-CoV-2 non-structural protein 10 (nsp10) is encoded within ORF1ab and is a cofactor for guanine-N7 methyltransferase (guanine-N7 MTase) and 2'-O-methyltransferase (2'-O-MTase). The amino acid sequence of nsp10 displays few mutations and is highly conserved across SARS-CoV-2 variants. SARS-CoV-2 nsp10 binds to and stabilizes the disordered N-terminal exoribonuclease domain (ExoN domain) of guanine-N7 MTase and is necessary for accurate exonuclease activity. It forms a complex with 2'-O-MTase to methylate nascent mRNAs at the ribose 2'-O position, creating a Cap-1 structure that facilitates increased translation of viral mRNAs and reduced innate immune recognition by the host cell.Synonyms: SARS-CoV-2 Non-structural Protein 10, Severe Acute Respiratory Syndrome Coronavirus 2 nsp10. Purity: >90%. Endotoxin Testing: < 1.0 EU/µg, determined by the LAL endotoxin assay. Source: Recombinant SARS-CoV-2 N-terminal His-tagged nsp10 expressed in E. coli. Amino Acids: 1-139 (full length). Formulation: (Request formulation change), 50 mM Tris-HCl, pH 7.5, with 200 mM sodium chloride and 20% glycerol. UniProt Accession #: P0DTD1.
Keywords: rep, GFL, Pol, Hel, nsp1, nsp2, nsp3, nsp4, 3CLp, Mpro, nsp5, nsp6, nsp7, nsp8, nsp9, RdRp, ExoN, 1a-1b, pp1ab, nsp10, nsp12, nsp13, nsp14, nsp15, nsp16, PL-PRO, NendoU, PL2-PRO, 3CL-PRO, Helicase, p65 homolog, Main protease, Leader protein, ORF1ab polypr
Supplier: Cayman Chemical
Supplier-Nr: 40883

Properties

Conjugate: No
Host: E.coli
Species reactivity: SARS-CoV-2
Purity: >90%
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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