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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| G-RPCB1191.96 | 10 µg | - | - | - |
9 - 20 business days* |
641.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Endotoxin Levels: < 0.01EU/µg Protein function: Activator of the canonical Wnt signaling pathway... more
Product information "Recombinant Mouse R-spondin-1/RSPO1 Protein"
Endotoxin Levels: < 0.01EU/µg Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646). Also regulates the canonical Wnt/beta-catenin- dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1. [The UniProt Consortium]
| Keywords: | Rspo1, Cristin-3, mCristin-3, R-spondin-1, Roof plate-specific spondin-1, Cysteine-rich and single thrombospondin domain-containing protein 3 |
| Supplier: | Assay Genie |
| Supplier-Nr: | RPCB1191 |
Properties
| Conjugate: | No |
| Host: | Human cells |
| Species reactivity: | mouse |
| Purity: | >97% |
Database Information
| KEGG ID : | K19471 | Matching products |
| UniProt ID : | Q9Z132 | Matching products |
| Gene ID : | GeneID 192199 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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