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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-32-8624-10 | 10 µg | - | - |
3 - 11 business days* |
546.00€
|
||
ABE-32-8624-50 | 50 µg | - | - |
3 - 11 business days* |
979.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Source: Human Cells. MW :46.2kD. Recombinant Mouse LAG-3 is produced by our Mammalian expression... more
Product information "Recombinant Mouse Lymphocyte Activation Gene 3/LAG-3/CD223 (C-6His)"
Source: Human Cells. MW :46.2kD. Recombinant Mouse LAG-3 is produced by our Mammalian expression system and the target gene encoding Ser23-Leu442 is expressed with a 6His tag at the C-terminus. Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug. Protein function: Involved in lymphocyte activation. Binds to HLA class-II antigens. [The UniProt Consortium]
Supplier: | Abeomics |
Supplier-Nr: | 32-8624 |
Properties
Conjugate: | No |
Database Information
KEGG ID : | K06565 | Matching products |
UniProt ID : | Q61790 | Matching products |
Gene ID : | GeneID 16768 | Matching products |
Handling & Safety
Storage: | +20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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