Recombinant Human CD19 (C-Fc)

Recombinant Human CD19 (C-Fc)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-7516-10 10 µg - -

3 - 11 business days*

478.00€
ABE-32-7516-50 50 µg - -

3 - 11 business days*

791.00€
 
Source: Human Cells. MW :57.3kD. Recombinant Human CD19 is produced by our Mammalian expression... more
Product information "Recombinant Human CD19 (C-Fc)"
Source: Human Cells. MW :57.3kD. Recombinant Human CD19 is produced by our Mammalian expression system and the target gene encoding Pro20-Lys291 is expressed with a Fc tag at the C-terminus. CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. Protein function: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-7516

Properties

Conjugate: No

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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