RBP4, Recombinant, Rat (Retinol Binding Protein 4)

Retinol binding protein 4 (RBP4, RBP) is a 21kD secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function. Sequence: Rat RBP4 (aa19-201) is fused at the N-terminus to a FLAG(R)-tag, expressed in HEK 293 cells. Molecular Weight: ~23kD (SDS-PAGE), Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.