PRMT6 Protein, Human, Recombinant (His & Flag)

PRMT6 Protein, Human, Recombinant (His & Flag)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
TGM-TMPY-01383-50ug 50 µg -

7 - 10 business days*

599.00€
 
Description: Protein arginine N-methyltransferase 6, also known as Histone-arginine... more
Product information "PRMT6 Protein, Human, Recombinant (His & Flag)"
Description: Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression. PRMT6 plays a key role in coupling process by functioning as a transcriptional coactivator that can regulate alternative splicing. PRMT6 coactivates the progesterone, glucocorticoid and oestrogen receptors in luciferase reporter assays in a hormone-dependent manner. Small interfering RNA (siRNA) oligonucleotide duplex knockdown of PRMT6 disrupts oestrogen-stimulated transcription of endogenous GREB1 and progesterone receptor in MCF-7 breast cancer cells. Neutralizing the activity of PRMT6 could inhibit tumor progression and may be of cancer therapeutic significance.
Keywords: protein arginine methyltransferase 6, HRMT1L6
Supplier: TargetMol
Supplier-Nr: TMPY-01383

Properties

Conjugate: No
MW: 44.4 kD

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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