Platelet glycoprotein Ib alpha chain (GP1BA), partial, human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 17-505aa. Protein Length: Partial of BC027955. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: HPICEVSKVA SHLEVNCDKR NLTALPPDLP KDTTILHLSE NLLYTFSLAT LMPYTRLTQL NLDRCELTKL QVDGTLPVLG TLDLSHNQLQ SLPLLGQTLP ALTVLDVSFN RLTSLPLGAL RGLGELQELY LKGNELKTLP PGLLTPTPKL EKLSLANNNL TELPAGLLNG LENLDTLLLQ ENSLYTIPKG FFGSHLLPFA FLHGNPWLCN CEILYFRRWL QDNAENVYVW KQGVDVKAMT SNVASVQCDN SDKFPVYKYP GKGCPTLGDE GDTDLYDYYP EEDTEGDKVR ATRTVVKFPT KAHTTPWGLF YSWSTASLDS QMPSSLHPTQ ESTKEQTTFP PRWTPNFTLH MESITFSKTP KSTTEPTPSP TTSEPVPEPA PNMTTLEPTP SPTTPEPTSE PAPSPTTPEP TPIPTIATSP TILVSATSLI TPKSTFLTTT KPVSLLESTK KTIPELDQPP KLRGVLQGHL ESSRNDPFLH PDFCCLLPL. Protein function: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. [The UniProt Consortium]. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: GP-Ib, a surface mbrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Reference: Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene.Salomon O., Rosenberg N., Steinberg D.M., Huna-Baron R., Moisseiev J., Dardik R., Goldan O., Kurtz S., Ifrah A., Seligsohn U.Ophthalmology 111:184-188(2004). Function: nan