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![PEPCK-C protein (His tag), recombinant rat](https://www.biomol.com/media/image/61/7b/8f/E-PDER100033-20_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PDER100033.20 | 20 µg | - |
7 - 16 business days* |
81.00€
|
|||
E-PDER100033.100 | 100 µg | - |
7 - 16 business days* |
141.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Testing in progress Protein Construction: A DNA sequence encoding the Rat PEPCK-C... more
Product information "PEPCK-C protein (His tag), recombinant rat"
Activity: Testing in progress Protein Construction: A DNA sequence encoding the Rat PEPCK-C protein (P07379) (Met 1-Lys 135) was expressed with a N-His tag. Sequence: Met 1-Lys 135. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 15 kDa. Protein function: PCK1 (Phosphoenolpyruvate carboxykinase 1, also PEPCK-C [cytosolic]) is a monomeric, 67-68 kDa member of the PEP carboxykinase family of enzymes. It is expressed in postnatal cells such as mammary epithelium, white and brown adipocytes, skeletal muscle Protein function: Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:4186849, PubMed:30193097, PubMed:26322521, PubMed:26709450, PubMed:28345895, PubMed:31461616). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up- regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis. The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis. In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor. The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis- related genes. [The UniProt Consortium]
Keywords: | PEPCK-C, Serine-protein kinase PCK1, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], Recombinant Rat PEPCK-C protein (His tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PDER100033 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | rat |
MW: | 14.74 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K01596 | Matching products |
UniProt ID : | P07379 | Matching products |
Gene ID | GeneID 362282 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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