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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay36952-50 | 50 µg | - |
6 - 10 business days* |
539.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Programmed cell death 1 ligand 1 (PD-L1), also known as B7-H1 or CD274, is a B7 family protein... more
Product information "PD-L1 Extracellular Domain (human, recombinant) - Biotinylated"
Programmed cell death 1 ligand 1 (PD-L1), also known as B7-H1 or CD274, is a B7 family protein that is involved in regulation and attenuation of the adaptive immune response and peripheral T cell tolerance. It is a 290-amino acid type I transmembrane protein encoded by CD274 in humans and is composed of a 239-amino acid extracellular domain consisting of a signal peptide, an IgV-like domain, and an IgC-like domain, a transmembrane domain, and a cytoplasmic tail. PD-L1 is constitutively expressed in T and B cells, dendritic cells, macrophages, and regulatory T cells (Tregs), as well as a variety of nonhematopoietic cells, and is upregulated by IFN-gamma. Binding of PD-L1 to its receptor, programmed cell death protein 1 (PD-1), suppresses T cell proliferation, migration, and cytokine production. PD-L1 is also aberrantly expressed in a variety of tumor cells, and expression of PD-L1 in tumor tissue is associated with poor prognosis in patients with renal cell carcinoma. Formulations containing PD-L1 blocking antibodies have been used in the treatment of a variety of cancers. Cayman's PD-L1 Extracellular Domain (human, recombinant) - Biotinylated protein contains purified PD-L1 that has been biotinylated via the E. coli biotin ligase enzyme BirA, which was subsequently depleted by affinity chromatography. It consists of 253 amino acids including the purification tag, has a calculated molecular weight of 27.1 kDa, and a predicted N-terminus of Phe19 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 35 kDa due to post-translational modifications.Synonyms: B7 Homolog 1, B7-H1, CD274, hPD-L1, PDCD1 Ligand 1, Programmed Cell Death Ligand 1, Programmed Cell Death Protein Ligand 1. Purity: >90%. Source: Recombinant human C-terminal AVI-tagged PD-L1 expressed in HEK293 cells. Amino Acids: 19-239. MW: 27.1. Formulation: (Request formulation change), 50 mM Tris hydrochloride, pH 8.0, with 100 mM sodium chloride. UniProt Accession #: Q9NZQ7.
Keywords: | B7H1, PD-L1, B7-H1, CD274, PD-L1, B7-H1, CD274, hPD-L1, hPD-L1, B7 homolog 1, B7 homolog 1, PDCD1 ligand 1, PDCD1 ligand 1, Programmed death ligand 1, Programmed death ligand 1, Programmed cell death 1 ligand 1, Programmed cell death 1 ligand 1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 36952 |
Properties
Conjugate: | Biotin |
Purity: | >90% |
Format: | Solution |
Database Information
KEGG ID : | K06745 | Matching products |
UniProt ID : | Q9NZQ7 | Matching products |
Gene ID : | GeneID 29126 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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