PD-1 Protein (canine), hFc Tag

Description: Recombinant Canine PD-1 protein with C-terminal human Fc tag Background: Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells, it is involved in the regulation of T-cell functions, including those of effector CD8 T cells. In addition, this protein can also promote the differentiation of CD4 T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. Molecular Characterization: mass of 42.3 kDa after removal of the signal peptide. The apparent molecular mass of dPD-1-hFc is approximately 55-70 kDa due to glycosylation. Tag: C-Human Fc tag