OX40:Fc, Recombinant, Human (TNFRSF 4, Tumor Necrosis Factor Receptor Superfamily Member 4, CD134)

OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully. Biological Activity: Blocks T cell proliferation induced by CD134L. Sequence: Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4°C, Long-term Storage: -20°C, Stable for at least 6 months after receipt when stored at -20°C.