Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial, human, recombinant

Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 589-875aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: ITQLSHLGQG TRTNVYEGRL RVEGSGDPEE GKMDDEDPLV PGRDRGQELR VVLKVLDPSH HDIALAFYET ASLMSQVSHT HLAFVHGVCV RGPENIMVTE YVEHGPLDVW LRRERGHVPM AWKMVVAQQL ASALSYLENK NLVHGNVCGR NILLARLGLA EGTSPFIKLS DPGVGLGALS REERVERIPW LAPECLPGGA NSLSTAMDKW GFGATLLEIC FDGEAPLQSR SPSEKEHFYQ RQHRLPEPSC PQLATLTSQC LTYEPTQRPS FRTILRDLTR LQPHNLA. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Reference: "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase." Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J. Mol. Cell. Biol. 14:8133-8142(1994). Function: nan