Nectin-4 (C-Fc) (recombinant mouse)

Activity: Immobilized Recombinant Mouse Nectin-4 (C-6His)(Cat#PKSM041376) at 10µg/ml (100 µl/well) can bind Recombinant Mouse Nectin-4 (C-Fc)(Cat#PKSM041375). The ED50 of PKSM041375 is 0.75 ug/ml. Protein Construction: Recombinant Mouse Poliovirus Receptor-Related Protein  4 is produced by our Mammalian expression system and the target gene encoding Gly31-Ser349 is expressed with a Fc tag at the C-terminus. Sequence: Gly31-Ser349. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Apparent Molecular Mass: 75-85kDa. Protein function: Nectin-4(PVRL4)isatypeItransmembraneglycoproteinwhichbelongstothenectinfamilyofIgsuperfamilyproteins.ItcontainstwoIg-likeC2-typedomainsandoneIg-likeV-typedomain.PVRL4seemstobeinvolvedincelladhesionthroughtrans-homophilicand-heterophilicinteractions,thelatterincludingspecificallyinteractionswithnectin-1.Itdoesnotactasreceptorforalpha-herpesvirusentryintocells.Itispredominantlyexpressedinplacenta,theembryoandbreastcarcinoma.Butitisnotdetectedinnormalbreastepithelium.Thesolubleformisproducedbyproteolyticcleavageatthecellsurface(shedding),probablybyADAM17.Mutationsinthisgenearethecauseofectodermaldysplasia-syndactylysyndrometype 1, an autosomal recessive disorder. Protein function: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. [The UniProt Consortium]