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![Mpro [3CLpro] (SARS-CoV-2) (rec.) (His)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
SBB-DE0129-C050 | 50 µg | - | - |
3 - 9 business days* |
370.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mpro (Papain-like Protease) (aa 1540-1841) (Accession Nr. P0C6U8) is fused at the N-terminus to a... more
Product information "Mpro [3CLpro] (SARS-CoV-2) (rec.) (His)"
Mpro (Papain-like Protease) (aa 1540-1841) (Accession Nr. P0C6U8) is fused at the N-terminus to a His-tag. 3CLpro recognizes the peptide sequence LQ[S/A/G] where it cleaves c-terminal to the amino acid glutamine (use product SBB-PS0130, KTSAVLQ-Rh110-Glu as universal substrate). The protease 3CLpro is a potential drug target for coronavirus infections due to its essential role in processing the polyproteins that are translated from the viral RNA. The X-ray structures of the unliganded SARS-CoV-2 protease 3CLpro and its complex with an alpha-ketoamide inhibitor provides a basis for design of a-ketoamide inhibitors. This SARS Coronavirus recombinant 3CLpro is N-terminally His10-tagged and expressed in E.coli. 3CLpro recognizes the peptide sequence LQ[S/A/G] where it cleaves C-terminal to the amino acid glutamine. Working concentrations of this enzyme range from 10 to 100 nM using KTSAVLQ-Rh110 (SBB-PS0130) as substrate.
Keywords: | Chymotrypsin Like Protease, SARS Coronavirus Main Proteinase |
Supplier: | South Bay Bio |
Supplier-Nr: | DE0129 |
Properties
Application: | Assays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | SARS-CoV-2 |
MW: | 36 kD |
Purity: | >98% |
Format: | Liquid |
Database Information
UniProt ID : | P0C6U8 | Matching products |
Gene ID | GeneID 1489680 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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