Mouse B7-H2 Protein, hFc Tag

Recombinant mouse B7-H2 protein with C-terminal human Fc tag. Mouse B7-H2(Glu47-Lys279) hFc(Glu99-Ala330), Protein function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion, induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype. [The UniProt Consortium]