Mouse B7-2 Protein, hFc Tag

Recombinant mouse B7-2 protein with C-terminal human Fc tag. Mouse B7-2(Val24-Glu245) hFc(Glu99-Ala330), Protein function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883). [The UniProt Consortium]