Macrophage mannose receptor 1 (MRC1), partial, human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 655-1213aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: RTSLCFKLYA KGKHEKKTWF ESRDFCRALG GDLASINNKE EQQTIWRLIT ASGSYHKLFW LGLTYGSPSE GFTWSDGSPV SYENWAYGEP NNYQNVEYCG ELKGDPTMSW NDINCEHLNN WICQIQKGQT PKPEPTPAPQ DNPPVTEDGW VIYKDYQYYF SKEKETMDNA RAFCKRNFGD LVSIQSESEK KFLWKYVNRN DAQSAYFIGL LISLDKKFAW MDGSKVDYVS WATGEPNFAN EDENCVTMYS NSGFWNDINC GYPNAFICQR HNSSINATTV MPTMPSVPSG CKEGWNFYSN KCFKIFGFME EERKNWQEAR KACIGFGGNL VSIQNEKEQA FLTYHMKDST FSAWTGLNDV NSEHTFLWTD GRGVHYTNWG KGYPGGRRSS LSYEDADCVV IIGGASNEAG KWMDDTCDSK RGYICQTRSD PSLTNPPATI QTDGFVKYGK SSYSLMRQKF QWHEAETYCK LHNSLIASIL DPYSNAFAWL QMETSNERVW IALNSNLTDN QYTWTDKWRV RYTNWAADEP KLKSACVYLD LDGYWKTAHC NESFYFLCK. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E. Interacts with hepatitis B virus envelope protein. Reference: "Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains." Taylor M.E., Conary J.T., Lennartz M.R., Stahl P.D., Drickamer K. J. Biol. Chem. 265:12156-12162(1990). Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains., FUNCTION