LILRB5 Protein (human), His Tag

Description: Recombinant Human LILRB5 Protein with C-terminal 6-His tag Background: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. Molecular Characterization: mass of 48.1 kDa after removal of the signal peptide. The apparent molecular mass of LILRB5-His is approximately 55-70 kDa due to glycosylation. Tag: C-6-His Tag Protein function: May act as receptor for class I MHC antigens. [The UniProt Consortium]