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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
SBB-UP0063-C025 | 25 µg | - | - |
3 - 9 business days* |
211.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recombinant Protein. Two enzymatically conjugated human ubiquitin (aa1-76) covalently linked... more
Product information "K11-linked Di-Ubiquitin (human) (rec.) (untagged)"
Recombinant Protein. Two enzymatically conjugated human ubiquitin (aa1-76) covalently linked through an isopeptide bond at K11 residue of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin molecule and untagged. Source/Host: E. coli. Liquid. In 50mM HEPES pH 7.5. The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural diversity of differently linked ubiquitin chains. In a ubiquitin chain, ubiquitin moieties can be conjugated through one of their lysine residues (K6, K11, K27, K29, K33, K48 and K63) or the N-terminal methionine residue (M1), offering countless possibilities to assemble a specific polymer. Ubiquitin molecules can also be modified by other post-translational modifications, including acetylation and phosphorylation, adding another layer of ubiquitin signal regulation and diversification. The abundance of K11 linkages strongly increase when the metazoan anaphase-promoting complex APC/C is active during mitosis, and APC/C has been shown to assemble K11-linked ubiquitin chains to drive proteasomal degradation and exit from mitosis. This protein is formed with wild-type human recombinant ubiquitin and linkage-specific enzymes. Ideal for investigating ubiquitin-binding proteins and as substrates for ubiquitin-specific isopeptidases. Reaction conditions will need to be optimized for each specific application.
Keywords: | Ub2 |
Supplier: | South Bay Bio |
Supplier-Nr: | UP0063 |
Properties
Conjugate: | No |
Host: | E. coli |
Species reactivity: | human |
MW: | 17 kD |
Purity: | >95% (SDS-PAGE) |
Format: | Solution |
Database Information
KEGG ID : | K04551 | Matching products |
UniProt ID : | P0CG47 | Matching products |
Gene ID : | GeneID 7314 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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