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
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
TGM-TMPY-04554-50ug | 50 µg | - |
7 - 10 business days* |
397.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the... more
Product information "JNK1 Protein, Human, Recombinant (GST)"
Description: Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in the promotion of diet-induced obesity, metabolic inflammation, and beta-cell dysfunction. The selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. Genetic analysis indicates that the effects of JNK1 can be separated from the effects of JNK1 on obesity. JNK1 is a potential pharmacological target for the development of drugs that might be useful for the treatment of metabolic syndrome, and type 2 diabetes. Furthermore, JNK1 plays a major role in hypoxic cellular damage. JNK1 protein might be an attractive target for anti-hypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.
Keywords: | PRKM8, JNK, SAPK1, mitogen-activated protein kinase 8, JNK1A2, JNK21B1/2, JNK-46, JNK1, SAPK1c |
Supplier: | TargetMol |
Supplier-Nr: | TMPY-04554 |
Properties
Conjugate: | No |
MW: | 75 kD |
Database Information
KEGG ID : | K04440 | Matching products |
UniProt ID : | P45983 | Matching products |
Gene ID : | GeneID 5599 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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