HVEM/TNFRSF14, Recombinant, Mouse, aa39-206, hIgG-His-Tag

HVEM/TNFRSF14, also known as tumor necrosis factor receptor superfamily member 14, is a member of TNF receptor superfamily. This protein was originally known as herpes virus entry mediator A (HveA), HveB and HveC are structurally unrelated proteins of the immunoglobulin superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response. It promotes and inhibits T cell activity. This protein signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. It participates in cell to cell contact signaling between antigen presenting cells and lymphocytes. This protein downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. Source: Recombinant protein corresponding to aa39-206 from mouse HVEM/TNFRSF14 fused to higG-His-tag at C-terminal, expressed in Baculovirus.. Molecular Weight: ~45.3kD (407aa), Endotoxin: ~1EU/1ug (LAL), AA Sequence: QPSCRQEEFL VGDECCPMCN PGYHVKQVCS EHTGTVCAPC PPQTYTAHAN GLSKCLPCGV CDPDMGLLTW QECSSWKDTV CRCIPGYFCE NQDGSHCSTC LQHTTCPPGQ RVEKRGTHDQ DTVCADCLTG TFSLGGTQEE CLPWTNCSAF QQEVRRGTNS TDTTCSSQLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH, Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.