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![HVEM/TNFRSF14 Protein (Fc Tag) (recombinant mouse)](https://www.biomol.com/media/image/85/71/d4/E-PDMM100072-20_600x600.jpg)
NEW
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PDMM100072.20 | 20 µg | - | - |
7 - 16 business days* |
248.00€
|
||
E-PDMM100072.100 | 100 µg | - | - |
7 - 16 business days* |
742.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Sequence: Gln39-Tyr210. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg of the protein as determined... more
Product information "HVEM/TNFRSF14 Protein (Fc Tag) (recombinant mouse)"
Sequence: Gln39-Tyr210. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 50-60 kDa. Protein function: Protein function: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:25711213). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (PubMed:22801499). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:15568026, PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:15568026, PubMed:19915044). [The UniProt Consortium]
Keywords: | TR2, HveA, CD270, Herpesvirus entry mediator A, Herpes virus entry mediator A, Tumor necrosis factor receptor-like 2, Tumor necrosis factor receptor superfamily member 14, Recombinant Mouse HVEM/TNFRSF14 Protein(Fc Tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PDMM100072 |
Properties
Conjugate: | No |
Host: | Mammalian |
Species reactivity: | mouse |
Format: | Lyophilized |
Database Information
KEGG ID : | K05152 | Matching products |
UniProt ID : | Q80WM9 | Matching products |
Gene ID | GeneID 230979 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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