Human DR3/TNFRSF25 Protein

Recombinant Human DR3/TNFRSF25 Protein is expressed from HEK293 with His tag and hFc tag at the C-terminus.It contains Gln25-Gln199. Death Receptor 3 (DR3), also known as TNFRSF25, TRAMP, LARD, or WSL-1, is a death-domain-containing TNF-family receptor that, like its closest paralog TNFR1, binds the adaptor molecule TRADD through its cytoplasmic death domain. TRADD recruitment endows DR3 with dual-signaling capability to activate NF-kappaB and MAP-kinase signaling or alternatively trigger caspase activation and programmed cell death. Protein function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. [The UniProt Consortium]