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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay14944-250 | 250 µg | - |
6 - 10 business days* |
417.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER)... more
Product information "HMG-CoA Reductase (human recombinant)"
HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol. HMGR is controlled by feedback regulation from sterols and non-sterol metabolites derived from mevalonate. Binding of cholesterol derived from internalized LDL receptors suppresses HMGR. The enzyme is responsible for catalyzing the rate-limiting step in cholesterol biosynthesis. Mevalonate, which is converted to isopentenyl pyrophosphate, is the building block for cholesterol and non-sterol isoprenoids. The four-electron reduction of HMG-CoA catalyzed by HMGR to form mevalonate is the committed step in the biosynthesis of sterols and isoprenoids. Potent inhibitors of HMGR, collectively called statins, are effective in lowering mortality due to hypercholesterolemia by lowering serum cholesterol levels.Synonyms: 3-hydroxy-3-methylglutaryl-Coenzyme A Reductase, HMGCR, HMGR. Purity: >85% estimated by SDS-PAGE. Source: recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 426-888 (N-terminal truncation). MW: 76.5 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, with 300 mM sodium chloride and 20% glycerol. UniProt Accession #: P04035.
Keywords: | HMG-CoA reductase, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14944 |
Properties
Application: | Enzyme activity |
Conjugate: | No |
Species reactivity: | human |
MW: | 76.5 kD |
Purity: | >85% estimated by SDS-PAGE |
Format: | Purified |
Database Information
KEGG ID : | K00021 | Matching products |
UniProt ID : | P04035 | Matching products |
Gene ID : | GeneID 3156 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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