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![Histone H3 (human, recombinant)](https://www.biomol.com/media/image/f1/6b/3c/Cay10263-1_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10263-1 | 1 mg | - |
6 - 10 business days* |
732.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of... more
Product information "Histone H3 (human, recombinant)"
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination. Histone H3 PTMs function as epigenetic regulators of gene transcription by affecting chromatin structure and providing binding sites for many transcription factors, thus regulating several cellular functions including gene expression, cell cycle, and DNA replication and repair. Differential methylation of histone H3 at various lysine residues is catalyzed by SET domain-containing methyltransferases and marks sites of transcriptional activation or repression. Citrullination of histone H3 by protein arginine deiminase 4 (PAD4, Cay-10500, Cay-25915, Cay-28910) or PAD2 (Cay-10785) induces the release of neutrophil extracellular traps (NETs), a network of decondensed DNA and intracellular proteins secreted by neutrophils as a pathogen defense mechanism. Histone H3 mutations have been found in patients with diffuse intrinsic pontine glioma, leukemia, or chondroblastoma.Synonyms: H3C1, Histone H3.1. Purity: >95% estimated by SDS-PAGE. Protein Identity Confirmed by Mass Spec: Yes. Source: Recombinant human histone H3 expressed in E. coli. Amino Acids: 1-136 (full length). MW: 15.5 kDa. Formulation: (Request formulation change), A solution in water (frozen). UniProt Accession #: P68431.
Keywords: | H3FA, H3FL, H3FB, H3FD, H3FI, H3FH, H3FK, H3FF, H3FJ, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, Histone H3.1, Histone H3/a, Histone H3/b, Histo |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10263 |
Properties
Application: | WB |
Conjugate: | No |
Host: | E.coli |
MW: | 15,5 kD |
Purity: | >95% estimated by SDS-PAGE |
Format: | Solid |
Database Information
KEGG ID : | K11253 | Matching products |
UniProt ID : | P68431 | Matching products |
Gene ID | GeneID 8350 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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