(Glp1)-Apelin-13 (trifluoroacetate salt)

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Cay-13524), apelin-17, and apelin-13 (Cay-13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. (Glp1)-Apelin-13 is a pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid. Like apelin-13, this compound is a potent APJ receptor agonist (EC50 = 0.30 nM). (Glp1)-Apelin-13 is the major apelin isoform in the plasma of healthy human subjects. It can have vasoconstrictor and antipyretic effects in vitro and in vivo.Formal Name: 5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine, trifluoroacetate salt. Synonyms: (pGlu1)Apelin-13, Pyr-Apelin-13, (Pyr1)Apelin-13. Molecular Formula: C69H108N22O16S . XCF3COOH. Formula Weight: 1533.8. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: XRPRLSHKGPMPF (Modifications: X = pGlu). Solubility: Water: 10 mg/ml. SMILES: O=C(N(CCC1)[C@@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N(CCC2)[C@@H]2C(N[C@@H](CCSC)C(N(CCC3)[C@@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)CC5=CNC=N5)=O)=O)=O)=O)[C@H](CCCNC(N)=N)NC([C@@H](N6)CCC6=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C69H108N22O16S.C2HF3O2/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55(94)89-28-11-19-51(89)62(101)84-46(24-31-108-3)66(105)91-30-13-21-53(91)64(103)87-49(67(106)107)33-40-14-5-4-6-15-40,3-2(4,5)1(6)7/h4-6,14-15,35,38-39,42-53,92H,7-13,16-34,36-37,70H2,1-3H3,(H,75,79)(H,78,95)(H,80,93)(H,81,99)(H,82,102)(H,83,97)(H,84,101)(H,85,96)(H,86,100)(H,87,103)(H,88,98)(H,106,107)(H4,71,72,76)(H4,73,74,77),(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,/m0./s1. InChi Key: LMXSVBHOGMJENQ-PDGAQFIRSA-N.